Senescent cells and the incidence of age-related diseases
This article is from the Lab of Uri Alon looking at senescent cells in several age-related diseases. I am a follower of Alon for a few reasons. 1. He has extremely helpful youtubes on choosing a scientific project, how to pose a good scientific question, and how to give a good talk . I think…
Read MoreMy Research
2001 American Academy of Medical Acupuncture, Los AngelesAutonomic Nervous System activity during acupuncture treatment:A pilot study of patients with migraine 2004 Society for Acupuncture Research Presentation11th ANNUAL SOCIETY FOR ACUPUNCTURE RESEARCH SYMPOSIUMOctober 1-3, 2004 San Francisco, CAA Retrospective evaluation of Acupuncture outcomes as a function of Heart rate Variability 2007 Medical Acupuncture Article 2007 Analysis of Heart…
Read MoreHeat Shock Proteins and Neurodegenerative Diseases
More on specific heat shock proteins and their role in protection against neurogenerative diseases. Bohush A, Bieganowski P, Filipek A. Hsp90 and Its Co-Chaperones in Neurodegenerative Diseases. Int J Mol Sci. 2019;20(20):4976. Published 2019 Oct 9. doi:10.3390/ijms20204976 Abstract Proper folding is crucial for proteins to achieve functional activity in the cell. However, it often occurs that…
Read MoreCould Heat Therapy Be an Effective Treatment for Alzheimer’s and Parkinson’s Diseases?
This article looks at the benefits of sauna. It is an intervention that is relatively widely available. Most YMCA’s have them at the cost of a membership. There are home saunas also. The article states ” Heat shock proteins (HSPs) are chaperones that regulate the aggregation and disaggregation of proteins in intracellular and extracellular spaces,…
Read MoreCholinergic Modulation of Glial Function During Aging and Chronic Neuroinflammation
This is key to understanding how vagal activity, or cholinergic activity can mitigate the chronic inflammation found with Alzheimer’s disease. I have highlighted below the role of the (intimidating sounding) α7 nicotinic acetylcholine (α7nACh) receptors. These are receptors that are stimulated by acetylcholine the neurotransmitter found in vagal, or parasympathetic activity. These receptors are targeted in…
Read MoreOffspring of Centenarians-people who live to 100- are less likely to be frail due to genetic footprint
This finding, that offspring of centenarians are less likely to be frail, makes intuitive sense. People often refer to their parents “they lived to 90, so I will too” kind of reasoning. And there certainly seems to be some validity to it. When smoking was more of a problems than it is now, that was…
Read MoreThe Temin Effect in Science
I was unaware of this term! I like it! It refers to an observation that having a broader sense of knowledge in science but beyond that to the greater world, helps scientists to make important leaps of thought. These quantum shifts can help advance science further and yield truly innovative results. There are probably many…
Read MoreL-Serine, an Endogenous Amino Acid,Neuroprotective Agent for Neurological Disease, Alzheimer
This article discusses the supplement L-serine as a neuroprotective agent. It is quite safe and may have lots of benefits. I take it (when I remember ha ha!) I’ve discussed it before and the story of its discovery is fascinating. Ye L, Sun Y, Jiang Z, Wang G. L-Serine, an Endogenous Amino Acid, Is a…
Read MoreHelminth Immunomodulation in Autoimmune Disease.
This study relates to my interest in ways to modulate an overactive immune system. One radical way is to inoculate the patient with hookworm. Because hookworm has learned how to evade the immune system and coexist with humans, the thought is that it can put the brakes on immune overreaction. It doesn’t work reliably, unfortunately,…
Read MoreNeuroendocrineimmune system, Electroacupuncture and Gene Expression
This is an article included in my writing project and it doesn’t seem to be anywhere in my blog. So here it is! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862942/ Cooper EL. eCAM: Neuroendocrineimmune, Electroacupuncture and Gene Expression. Evid Based Complement Alternat Med. 2010;7(2):149-150. doi:10.1093/ecam/neq035 According to Burnet (5): The first objective in a serious approach to immunology should be to obtain…
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