David Sinclair Longevity Guru’s Failed Businesses
The article is worth a read if you’re interested and ends in this quote. “Sinclair said he believes that his companies will someday produce life-changing medicines. “Developing medicines that safely and effectively target aging,” he said, “is a difficult endeavor that has turned out to take longer than I expected.” I cited some of the…
Read MoreEffect of Electroacupuncture on HRV, heart rate variability in post-on-call trainees
This article is interesting to me for a few reasons. 1 It’s my previous profession, Anesthesiology! 2. I’ve been increasingly interested in sleep and sleep quality 3. HRV, in this study, was not changed by electroacupuncture according to their study design. I’ve looked at HRV and acupuncture for years. Low HJ, Cheah OK, Ng BH,…
Read MoreRapamycin for Anti-Aging: the latest science
From National Geographic: Rapamycin (red) inhibits a protein complex called mTORC1 (mammalian target of rapamycin complex 1, blue). It is mainly used to prevent rejection in organ transplantation, but some people are taking the drug for possible anti-aging benefits. So far, those benefits have not been proven in humans. (I wrote about MTOR in my…
Read MoreTAVNS and Chronic Knee Pain
We’ve discussed TAVNS or ear stimulation to increase vagal activity, here, here and here. This study is fascinating because it’s dealing with a condition that is “fixed”, ie, thought to be due to change in cartilage, and bone. Other pain types where is has been used, such as migraine are more episodic, multifactorial. Safety and…
Read MoreOld Friends and Early Life Stress
Thesis_Mazzari. old friends and stress pdf
Read MoreAcupuncture and Migraine: Combined with Beanembedding on Migraine and HRV
Nice study looking at acupuncture alone compared to acupuncture plus beanembedding. The beanembedding helped. Though there is supposed to be a free article, I can’t find it. Beanembedding is using of seeds instead of press needles in the ears. Of course, we’ve discussed migraine with acupuncture repeatedly on the blog! Lu Y, Sun Z, Huang…
Read MoreMind Magic by James Doty: Science of Manifestation
One of my classmates from Medical School published a popular book called Mind Magic by James Doty. It tells the tale of his overcoming an impoverished background in rural California, and becoming a wealthy neurosurgeon, only to have it all come crumbling down. Now, a professor at Stanford, he is head of the Dalai Lama…
Read MoreHallmarks of Aging: An Expanding Universe
This article has lots of detail about markers of aging. I’m not up to date on many of them, but some I’ve discussed before. I’ve covered telomeres, autophagy. And my book, Radical Resilience had an entire chapter on Longevity Science and Anti-Aging. Hallmarks of aging: An expanding universe López-Otín, Carlos et al. Cell, Volume 186,…
Read MoreMood and ALAN, Artificial Light at Night
Get your sleep! Artificial Light At Night may be harming you! I monitor my sleep with an oura ring and I think it’s really paid off. After reading about the hazards of light pollution, I started using an eye mask from manta.com. My youtube on artificial light at night here. Menculini G, Cirimbilli F, Raspa…
Read MoreArtificial Light at Night Increases Fat in Mice
Study showing that light at night can make fat cell growth worse. It disrupts melatonin and circadian rhythms, which has nasty effect on the body. Guan Q, Li Y, Wang Z, Cao J, Dong Y, Ren F, Chen Y. Monochromatic Light Pollution Exacerbates High-Fat Diet-Induced Adipocytic Hypertrophy in Mice. Cells. 2022 Nov 28;11(23):3808. doi: 10.3390/cells11233808….
Read More