Slow Aging, Huberman and David Sinclair
This is an Andrew Huberman episode with David Sinclair from a few years ago. Sinclair is under fire lately for unprofessional, overblown claims. I relied on his research for my chapter on Longevity in my book Radical Resilience, and so I have concerns about what his science actually shows! I’ve blogged about Sinclair’s work here and…
Read MoreChemical Cocktail to Reverse Aging?
Previous blog posts on David Sinclair here and here. I relied on his research for my book Radical Resilience. A brief video from my YouTube channel on the controversy. Review of new David Sinclair paper, supplements & anti-aging glitz
Read MoreKaeberlein Withdrawing from Academy for Health and Lifespan Research
Matt Kaeberlein withdraws from the Academny for Health and Lifespan Research because of over blow claims by Sinclair After careful consideration, I have renounced my membership in the Academy for Health and Lifespan Research ( @ahlresearc ). I find it deeply distressing that we’ve gotten to a point where dishonesty in science is normalized to…
Read MoreLife Span by David Sinclair A science-based review of the world’s best-selling book on aging,
I’m copying a rebuttal in full from 2023 to the ambitious claims laid out by David Sinclair in the TEDx talk below, and in his book “Life Span”. I’ve covered Sinclair on the blog here, and how his ideas correspond to the importance of the concept of hormesis here and here. I also discuss his…
Read MoreEffects of transcutaneous auricular vagus nerve stimulation at left cymba concha on experimental pain, parasympathetic activity
True prevention. In my book I highlight two studies in animals where acupuncture prevented an increase in stress response after startling the animal. This, to me, shows the power of prevention using acupuncture. It stabilized your stress response to that you don’t spin out. This is of utmost importance in understanding how acupuncture is so helpful…
Read Morebeneficial effects of honeybee-venom serum on facial wrinkles in humans
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598227/ The wrinkle depth decreased 10%. I have no idea if that would be discernible. The subjects in the study were convinced it helped. Han SM, Hong IP, Woo SO, Chun SN, Park KK, Nicholls YM, Pak SC. The beneficial effects of honeybee-venom serum on facial wrinkles in humans. Clin Interv Aging. 2015 Oct 1;10:1587-92….
Read MoreStatins Neuromuscular Adverse Effects
Attardo S, Musumeci O, Velardo D, Toscano A. Statins Neuromuscular Adverse Effects. Int J Mol Sci. 2022 Jul 28;23(15):8364. doi: 10.3390/ijms23158364. PMID: 35955495; PMCID: PMC9369175. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9369175/ Attardo S, Musumeci O, Velardo D, Toscano A. Statins Neuromuscular Adverse Effects. Int J Mol Sci. 2022 Jul 28;23(15):8364. doi: 10.3390/ijms23158364. PMID: 35955495; PMCID: PMC9369175. Statins are drugs widely…
Read MoreAcupuncture for primary insomnia: Effectiveness, safety, mechanisms and recommendations for clinical practice.
Primary insomnia (PI) is a growing concern, with cognitive-behavioral therapy as the first-line treatment, though accessibility and cost are issues. Hypnotics have risks and limited long-term effectiveness. Acupuncture is a potential treatment, showing improvements in subjective sleep quality, cognitive function, and emotional symptoms in clinical trials. It also enhances objective sleep measures and may restore…
Read MoreThe Anti-inflammatory baking soda effect is mediated by the splenic nerve
This DIY health hack was totally inknown to me, and I try to keep up with these sorts of low cost, safe solutions. Oral sodium bicarbonate (NaHCO3), baking soda, shows promise in treating inflammatory disorders by stimulating the inflammatory reflex (IR). Its mechanisms remain unclear. In a rat study, NaHCO3 increased anti-inflammatory markers and decreased…
Read MoreElectroacupuncture Exerts Analgesic Effects on Chronic Pain by Restoring Hyperactivity via Cannabinoid Type 1 Receptors in the Anterior Cingulate Cortex in Chronic Inflammatory
We know that acupuncture activates endorphins which help decrease pain, and that it also stimulates the vagus nerve from the periphery to the brainstem signalling the vagus. But this mechanism outlined in this study highlights the role of the brain on chronic pain in a specific brain regions with specific endocannabinoids. Point used was Stomach…
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