Tag: Neuromodulation

Medical Research

Supraspinal Mechanisms of Spinal Cord Stimulation for Modulation of Pain: Five Decades of Research and Prospects for the Future

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6338535/ Anesthesiology. Anesthesiology. 2019 Apr; 130(4): 651–665. Supraspinal Mechanisms of Spinal Cord Stimulation for Modulation of Pain: Five Decades of Research and Prospects for the Future Eellan Sivanesan, MD,1 Dermot Maher, MD, MS,1 Srinivasa N. Raja, MD,1 Bengt Linderoth, MD, PhD,2 and Yun Guan, MD, PhD1,3 Author information Copyright and License information Disclaimer Go to: Abstract The field of spinal cord stimulation…

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Health & Fitness

The effectiveness of electronic pulsed soft tissue vibration compared with topical anaesthesia in reducing the pain of injection of local anaesthetics in adults: a randomized controlled split-mouth clinical trial

Of interest to me because of the obvious parallel with the scratching I do before inserting needles.  In doing this type of  intervention you occupy the pain circuits with touch/vibration, an example of the “gating” principle popularized by Melzack and Wall back in the late 80’s.  Still alive and well and useful. https://www.sciencedirect.com/science/article/abs/pii/S0901502720302563 The effectiveness…

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Vagus nerve stimulation boosts the drive to work for rewards

Not sure what to make of this study.  But posting here because of the many and varied effects of the auricular branch of the vagus nerve. https://www.nature.com/articles/s41467-020-17344-9 Vagus nerve stimulation boosts the drive to work for rewards Monja P. Neuser, Vanessa Teckentrup, Anne Kühnel, Manfred Hallschmid, Martin Walter & Nils B. Kroemer Nature Communications volume 11,…

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The effects of transcutaneous vagus nerve stimulation on conditioned fear extinction in humans

https://www.sciencedirect.com/science/article/abs/pii/S1074742716300612 Neurobiology of Learning and Memory Volume 132, July 2016, Pages 49-56 The effects of transcutaneous vagus nerve stimulation on conditioned fear extinction in humans Author links open overlay panelAndreas M.Burgera BartVerkuilaIlseVan DiestbWillemVan der DoesaJulian F.ThayercJos F.Brosschota a Institute of Psychology, Leiden University, Wassenaarseweg 52, 2333 AK Leiden, The Netherlands b Faculty of Psychology, Katholieke…

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Vagus Nerve Stimulation and Neurotrophins: a biological psychiatric perspective

Ok.  A whole new area of brain chemistry I wasn’t aware of.  I’m not even sure where Neurotrophins are found.  Will report once I know.  I’m tempted to buy this article, but don’t want to get carried away. https://www.sciencedirect.com/science/article/abs/pii/S0149763419310516 Review article Vagus Nerve Stimulation and Neurotrophins: a biological psychiatric perspective Author links open overlay panelPamelaRossoa1AngelaIannitellib1FrancescaPacittibcAdeleQuartinibElenaFicoaMarcoFioreaAntonioGrecodMassimoRallidPaolaTirassaa…

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Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways.

Cell. 2017 Jun 29;170(1):185-198.e16. doi: 10.1016/j.cell.2017.05.034. Epub 2017 Jun 22. full article here Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways. Bellono NW1, Bayrer JR2, Leitch DB1, Castro J3, Zhang C1, O’Donnell TA3, Brierley SM3, Ingraham HA4, Julius D5. Author information 1 Department of Physiology, University of California, San Francisco, San Francisco,…

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Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology.

Nat Neurosci. 2012 Jul 26;15(8):1063-7. doi: 10.1038/nn.3144. full article here Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Chiu IM1, von Hehn CA, Woolf CJ. Author information 1 FM Kirby Neurobiology Center, Children’s Hospital Boston, Boston, Massachusetts, USA. Abstract The peripheral nervous and immune systems are traditionally thought of as serving…

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Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin.

Filing here for research work I’m doing.  Great original paper on the neuro-inflammatory response Nature. 2000 May 25;405(6785):458-62. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Borovikova LV1, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, Wang H, Abumrad N, Eaton JW, Tracey KJ. Author information Abstract Vertebrates achieve internal homeostasis…

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Pulse of Inflammation. HRV and the cholinergic pathway

Pulse of Inflammation. Heart Rate Variability, the cholinergic pathway, and Implications for therapy This paper is not new, but I was unaware of it before.  Tracey outlines some of the correlations between HRV and cytokine levels.  He makes the case that some diseases that are characterized by elevated cytokines, such as rheumatoid arthritis, may have…

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Investigational treatment of rheumatoid arthritis with a vibrotactile device applied to the external ear

Tracey has looked at HRV in conjunction with diseases of increased cytokines such as rhuematoid arthritis.  Too bad he didn’t look at it in this study. Bioelectron Med. 2019; 5: 4. Published online 2019 Apr 17. doi: 10.1186/s42234-019-0020-4 PMCID: PMC7098240 Investigational treatment of rheumatoid arthritis with a vibrotactile device applied to the external ear Meghan E….

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