electroacupuncture for stem cell release

Modern innovations for acupuncture — Ancient Medicine Made Modern

This study with a million authors is maily out of Florida. It’s pertinent for a variety of reasons. There is the remarkable fact that this huge group was able to get funding for such sophisticated acupuncture research and that it paid off. Way cool on all counts. Unfortunately, no emails available to try to get a reprint.

In this study, they conclude that LI11 and LI4 increase sympathetic activity, which is the opposite of what this study found. This might be of use to me, however, in explaining some of my results.

Stem Cells. 2017 Mar 16. doi: 10.1002/stem.2613. [Epub ahead of print]

Electroacupuncture Promotes CNS-Dependent Release of Mesenchymal Stem Cells.

Salazar TE^1,^2,³, Richardson MR⁴, Beli E², Ripsch MS⁵, George J³, Kim Y⁵, Duan Y², Moldovan L², Yan Y¹, Bhatwadekar A², Jadhav V², Smith JA⁵, McGorray S⁶, Bertone AL⁷, Traktuev DO^8,⁹, March KL^8,⁹, Colon-Perez LM¹⁰, Avin K¹¹, Sims E¹², Mund JA^4,¹², Case J^4,^12,^13,¹⁴, Deng S¹⁵, Kim MS¹⁶, McDavitt B¹⁷, Boulton ME², Thinschmidt J¹⁸, Li Calzi S², Fitz SD¹¹, Fuchs RK¹¹, Warden SJ¹¹, McKinley T¹⁹, Shekhar A²⁰, Febo M¹⁰, Johnson PL²¹, Chang LJ²², Gao Z²³, Kolonin MG²³, Lai S²⁴, Ma J²⁴, Dong X²⁵, White FA⁵, Xie H²⁶, Yoder MC^4,¹², Grant MB².

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Abstract

Electro-acupuncture (EA) performed in rats and humans using front-limb acupuncture sites, LI-4 and LI-11, and Du-14 and Du-20 increased functional connectivity between the anterior hypothalamus and the amygdala and mobilized mesenchymal stem cells (MSC) into the systemic circulation. In human subjects, the source of the MSC was found to be primarily adipose tissue whereas in rodents the tissue sources were considered more heterogeneous. Pharmacological disinhibition of rat hypothalamus enhanced sympathetic nervous system (SNS) activation and similarly resulted in a release of MSC into the circulation. EA-mediated SNS activation was further supported by browning of white adipose tissue in rats. EA treatment of rats undergoing partial rupture of the Achilles tendon resulted in reduced mechanical hyperalgesia, increased serum IL-10 levels and tendon remodeling, effects blocked in propranolol-treated rodents. To distinguish the afferent role of the peripheral nervous system, phosphoinositide-interacting regulator of transient receptor potential channels (Pirt)-GCaMP3 (genetically encoded calcium sensor) mice were treated with EA directed at hind limb immune points, ST-36 and Liv-3 and resulted in a rapid activation of primary sensory neurons. EA activated sensory ganglia and SNS centers to mediate the release of MSC that can enhance tissue repair, increase anti-inflammatory cytokine production and provide pronounced analgesic relief. This article is protected by copyright. All rights reserved.