beneficial effects of honeybee-venom serum on facial wrinkles in humans

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4598227/

The wrinkle depth decreased 10%. I have no idea if that would be discernible. The subjects in the study were convinced it helped.

Han SM, Hong IP, Woo SO, Chun SN, Park KK, Nicholls YM, Pak SC. The beneficial effects of honeybee-venom serum on facial wrinkles in humans. Clin Interv Aging. 2015 Oct 1;10:1587-92. doi: 10.2147/CIA.S84940. PMID: 26491274; PMCID: PMC4598227.

2015; 10: 1587–1592.

Published online 2015 Oct 1. doi: 10.2147/CIA.S84940

PMCID: PMC4598227

PMID: 26491274

The beneficial effects of honeybee-venom serum on facial wrinkles in humans

Sang Mi Han,¹ In Phyo Hong,¹ Soon Ok Woo,¹ Sung Nam Chun,² Kwan Kyu Park,³ Young Mee Nicholls,⁴ and Sok Cheon Pak⁵

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Abstract

Facial wrinkles are an undesirable outcome caused by extrinsic photodamage and intrinsic aging processes. Currently, no effective strategies are known to prevent facial wrinkles. We assessed the beneficial effects of bee-venom serum on the clinical signs of aging skin. Our results show that bee-venom serum treatment clinically improved facial wrinkles by decreasing total wrinkle area, total wrinkle count, and average wrinkle depth. Therefore, bee-venom serum may be effective for the improvement of skin wrinkles.

Keywords: bee venom, wrinkle, area, count, depth