Medical Research

The Physical Underpinnings of Anxiety

Kristen Sparrow • June 19, 2014

This study supports my own observations about anxiety and why acupuncture might help.  It calms the physical hyperarousal which then leads to thoughts which try to explain the physical sensations.  I finally was able to unearth the ISAMS 2013 Stockholm conference flash drive from my desk piles.  This abstract is from that.  I will attach the pdf of the entire talk here.Kjell Fuxe_ppt cns and acupuncture from ISAMs 2013

Understanding brain-body medicine through the integration of synaptic and volume transmission in key regions of the CNS
1, D. Borroto-Escuela1, G.Leo2, M. Guescini3, S. Genedani2, V. Stocchi3, C. Carone5, D.Sisti3, D. Guidolin6, L.F. Agnati5
The brain-body system aims to maintain the homeostasis of the internal milieu. The goal of the human brain-body system is also to maintain the milieu of “psychic homeostasis”, an autoregulated state of well-being to maintain a dynamic balance within the psychic sphere. Hypothalamus and nucleus tractus solitarius region are well-known to play an important role for the brain-body system and reciprocally interact. The function of these key regions for brain-body medicine is made possible through the balanced integration of volume transmission and synaptic transmission in the neuronal-glial networks.The receptor-receptor interactions in heteroreceptor complexes present at synaptic and extrasynaptic locations play an important role in this integrative process together with the endocrine signals. The new field of brain-body medicine builds on neuroimaging with fMRI and PET and gives strong support for the participation of cortical, especially prefrontal regions in regulation of endocrine, immune and autonomic responses via the medial prefrontal-brainstem axis based on correlative studies.There is a link between heart rate and anxiety. T
he β-adrenergic receptor agonist isoproterenol at a dose that has no direct effects on the CNS produced increases in the blood stream of extracellular vesicles which may contribute to the isoproterenol-induced anxious behavior and represent a novel peripheral signal modulating psychic homeostasis besides the visceral signals.
Key words: brain integration, brainstem, neuroimage, extracellular vesicles, volume transmission, receptor-receptor interactions
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden email:;
Department of Biomedical, Metabolic Sciences and Neuroscience, Physiology and Neuroscience Unit, University of Modena and Reggio Emilia, via Campi287, 41125, Modena, Italy email: ; ;
Department of Biomolecular Sciences, University of Urbino Carlo Bo, via I. Maggetti 26, 61029 Urbino (PU), Italy email: ; ;
Department of Diagnostic, Clinical Medicine and Public Health, University of Modena and Reggio Emilia, via Campi287, 41125, Modena, Italy