Health & Fitness

Systems Medicine 2020 Uri Alon

Kristen Sparrow • May 09, 2021

Systems Medicine 2020 Uri Alon

San Francisco Sity Sights. Nob Hill

I am stashing this link and series of links here since systems biology is very much a part of acupuncture and its results.  Small input of needling can lead to outsized results a  consequence of the cascades set in motion.  I’m working on the Immunology Chapter of my book “Deep Resilience” and I will need to be able to explain the principles of systems biology, a I have had to do in other chapter too.  I hope to have this extremely challenging chapter in some kind of shape within a few weeks.  It hasn’t help that all my work from yesterday wasn’t saved.  Bah!

Systems Medicine 2020

Lecture Notes and exercises 


Why Model?

A lecture by Joshua M. Epstein which he treats some enduring misconceptions about modeling. One of these is that the goal is always prediction. The lecture distinguishes between explanation and prediction as modeling goals, and offers sixteen reasons other than prediction to build a model. It also challenges the common assumption that scientific theories arise from and ‘summarize’ data, when often, theories precede and guide data collection; without theory, in other words, it is not clear what data to collect. Among other things, it also argues that the modeling enterprise enforces habits of mind essential to freedom.

How to solve ordinary differential equations? (tutorials in various common programing enviourments)

Lecture 1 – Epidemiology of COVID-19

Exercise 1 – Solution for Q3.

Lecture 2 – The insulin-glucose circuit 

Lecture 3 – Beta-cell tissue size control has fragilities that lead to type-2 diabetes: Dynamical compensation and mutant resistance in tissues

Exercise 2 – Solution (courtesy of Alon Bar)

Lecture 4 – Two-gland feedback in the stress-hormone axis generates seasonal clocks and explains clinical phenomena with a timescale of months

Lecture 5 – Addiction

Exercise 3 – Solution (by Alon Bar)

Lecture 6 – The immune system detects exponential threats

Lecture 7 – Autoimmune disease as a fragility of surveillance against hyper-secreting mutants

Lecture 8 – Inflammation and fibrosis as a bistable system

Exercise 4

Lecture 9 – Basic facts of aging

Lecture 10 – Aging and the saturation of damage removal

Lecture 11 – Aging-related diseases and their exponentially rising incidence with age.

Exercise 5 

Lecture 12 – Periodic table of diseases.