Medical Research

Corticotropin Releasing Factor Brain Peptides

Kristen Sparrow • April 01, 2019

This paper Cardiovascular functions of central corticotropin [PMIDP30922523]details the state of the knowledge of the various peptides involved in stress signaling in the brain.  The group is interested in acupuncture, but identified no specific directions of research involving acupuncture.  Since stress is a focus of mine in practice, I’m always looking for information that may help guide my project.

2019 Mar 20. pii: S0143-4179(18)30176-8. doi: 10.1016/j.npep.2019.03.006. [Epub ahead of print]

Cardiovascular functions of central corticotropin-releasing factor related peptides system.

Author information
Research Institute of Acupuncture and Meridian, Anhui University of Chinese Medicine, Hefei 230038, China. Electronic address:
Department of Pediatrics, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, China.


The corticotropin-releasing factor (CRF) related peptides system has widespread distributions in central nervous system, to perform many physiological and pathophysiological functions, including cardiovascular functions. A complex connection exists between the central CRF related peptides system and cardiovascular system. There are multiple pathways and mechanisms through which the central CRF related peptides system influences cardiovascular functions. A dysfunction in the central CRF related peptides system may lead to a wide range of alterations in cardiovascular functions. Though there are difficulties or limitations in establishing exact modulatory roles of the central CRF related peptides system in cardiovascular functions. The central CRF related peptides system as target to prevent cardiovascular diseases is being pursued with increasing interest. In this review, we summarize recent understanding on cardiovascular functions of the CRF related peptides system in limbic forebrain, hypothalamus and brain stem structures, discuss mechanisms of the central CRF related peptides system in control of cardiovascular functions, and suggest that the central CRF related peptides system may be a potent candidate for prevention of cardiovascular diseases.