Kristen Sparrow • April 11, 2021
More on the interaction of the neuroendocrine system and the immune system. Systems biology, it all goes together.. This article is only tangentially relevant to the question of acupuncture since it involves the overwhelming repercussions from massive trauma.
Yang C, Gao J, Du J, Yang X, Jiang J. Altered Neuroendocrine Immune Responses, a Two-Sword Weapon against Traumatic Inflammation. Int J Biol Sci. 2017;13(11):1409-1419. Published 2017 Nov 1. doi:10.7150/ijbs.21916
During the occurrence and development of injury (trauma, hemorrhagic shock, ischemia and hypoxia), the neuroendocrine and immune system act as a prominent navigation leader and possess an inter-system crosstalk between the reciprocal information dissemination. The fundamental reason that neuroendocrinology and immunology could mix each other and permeate toward the field of traumatology is owing to their same biological languages or chemical information molecules (hormones, neurotransmitters, neuropeptides, cytokines and their corresponding receptors) shared by the neuroendocrine and immune systems. The immune system is not only modulated by the neuroendocrine system, but also can modulate the biological functions of the neuroendocrine system. The interactive linkage of these three systems precipitates the complicated space-time patterns for the courses of traumatic inflammation. Recently, compelling evidence indicates that the network linkage pattern that initiating agents of neuroendocrine responses, regulatory elements of immune cells and effecter targets for immune regulatory molecules arouse the resistance mechanism disorders, which supplies the beneficial enlightenment for the diagnosis and therapy of traumatic complications from the view of translational medicine. Here we review the alternative protective and detrimental roles as well as possible mechanisms of the neuroendocrine immune responses in traumatic inflammation.