Kristen Sparrow • February 03, 2016
I spoke with this researcher and was very gratified by his results, since acupuncture fixed my allergies!
ACUPUNCTURE DOWNREGULATES HOUSE DUST
MITE SPECIFIC IGE AND SUBSTANCE P AND
IMPROVES SYMPTOMS AND QUALITY OF LIFE
IN ADULTS WITH PERSISTENT ALLERGIC RHINITIS
John L McDonald, Menzies Health Institute, Griffith University,
Queensland, Australia; Peter K Smith, Menzies Health Institute,
Griffith University, Queensland, Australia; Caroline A Smith,
National Institute of Complementary Medicine, University of
Western Sydney; Charlie CL Xue, Health Innovations Research
Institute and School of Health Sciences, RMIT University;
Brenda Golianu, Stanford University; Allan W Cripps, Menzies
Health Institute, Griffith University, Queensland, Australia
A growing body of clinical evidence suggests
that acupuncture improves symptoms in persistent allergic rhi-
nitis, but the physiological basis of these improvements is not
A randomized sham-controlled trial of acupuncture
for persistent allergic rhinitis (PAR) in adults was undertaken,
to investigate possible modulation of mucosal immune re-
sponses and changes in symptoms and quality of life.
151 subjects were randomized
into three groups: real
acupuncture, sham acupuncture and no acupuncture. Both acu-
puncture groups received twice we
ekly treatments for eight weeks.
The primary outcome measures were changes in cytokines, neu-
rotrophins, pro-inflammatory neuropeptides, immunoglobulins and
other inflammatory biomarkers in saliva or peripheral venous
blood plasma from baseline to f
our weeks after treatment. Sec-
ondary outcomes were measures of nasal airway resistance,
symptoms and quality of life scores throughout this period.
Statistically significant reduction in allergen-spe-
cific immunoglobulin E (IgE) for house dust mite was seen only
in the real acupuncture group, from 18.87
9.91 to 17.82
0.035). Statistically significant down-regulation was
also seen in pro-inflammatory neuropeptide Substance P (SP)
18 to 24 hours after the first treatment from 408.74
22.54 pg/ml (p
0.039). No significant changes were
seen in the other neuropeptides, neurotrophins or cytokines.
Symptoms and quality of life (Qol) scores improved signifi-
cantly with ongoing improvement at four weeks follow-up.
These symptomatic and Qol changes appeared to be associated
with reduction of house dust mite specific IgE, but not with
decreases in SP.
Acupuncture appears to be effective for adults
with PAR through down-regulating house dust mite-specific
IgE. Further studies are needed to confirm this finding.