Tag: autophagy
Astragalus and Longevity Astragalus membranaceus Injection Suppresses Production of Interleukin-6 by Activating Autophagy through the AMPK-mTOR Pathway in Lipopolysaccharide-Stimulated Macrophages.
This is a companion article to the previous astragalus article. Though herbal therapy is not my focus, I have been taking an Astragulus compound for over a decade (when I remember, ha ha.) It is a traditional anti-aging herb thought to have immune boosting properties as well. I take Astra Essence from Health Concerns. My…
Read MoreAcupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain
In the chapter of my book project “Deep Resilience” on Longevity-Chapter-for-blog-8.4.2020, the concept of autophagy and mTOR are laid out. Autophagy (the clearing of cells and their debris) is also important in Neurodegenerative Disease, such as Parkinson’s, Alzheimer’s and Huntington’s . This study is not new, having been completed in 2015, and perhaps there are…
Read MoreAcupuncture promotes mTOR-independent autophagic clearance of aggregation-prone proteins in mouse brain
This study is a bit complicated. They look at acupuncture at GB 34 and its effect on autophagy, dopamine and motor function in a mouse model of Parkinson’s condition. Though acupuncture increases autophagy of α-synuclein romoted the autophagic clearance of α-synuclein (α-syn), a well known aggregation-prone protein closely related to Parkinson’s disease (PD), in the…
Read MoreShort-term fasting induces profound neuronal autophagy.
This is an older study done in mice which shows that 24 hours of fasting produces upregulation of autophagy (cellular debris removal) in the brain. 48 hours produces even more. I’m not sure how many hours of fasting that would translate to for humans. Interesting! Though I have a tough time fasting for 16 hours,…
Read MoreAutophagy for Life Extension: Rhonda Patrick
Rhonda Patrick’s blog is focused on longevity research. She is a biochemist by training, but now devotes her time to making the arcane world of biochemisty research on aging accessible to the lay public. (In a recent podcast she discussed how she came to the decision to turn down a tenure track professorship at a…
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